About the Practical Course
Pangenomics has emerged as a transformative paradigm in genomics, moving from single linear reference genomes to pangenomesthat capture the full spectrum of genetic variation within species. Recent breakthroughs include the completion of the human pangenome reference by the Human Pangenome Reference Consortium (HPRC), revealing millions of previously hidden variants and structural variations that traditional approaches missed. Advanced graph-based representations now enable comprehensive analysis of complex genomic regions, including highly variable immune loci and centromeres.
Key technological advances include improved algorithms for pangenome construction (PGGB, WFMASH, IMPG), sophisticated visualization tools (ODGI), and novel genotyping methods from graph references (PanGenie, POVU). Course organizers and instructors contributed directly to HPRC, developing these cutting-edge methodologies and software. These advances are transforming genome evolution, population genetics, and disease research across diverse organisms.
This EMBO Practical Course addresses a critical gap in computational biology training. While pangenomics tools are rapidly advancing, researchers lack comprehensive hands-on experience with these specialized methods.
This EMBO Practical Course uniquely combines theoretical foundations with practical implementation across the entire pangenomics workflow—from graph construction through variant analysis. By training the next generation of computational biologists in these cutting-edge approaches, we will accelerate the adoption of pangenomics methods and enable more complete characterization of genetic diversity in research worldwide.
Artwork by Birdcap
IT Support
The cloud infrastructure for the course was set up and managed by Francesco Debiase, research fellow at INFN (Italian National Institute for Nuclear Physics). This included configuring the hosts, storage and software environments, as well as coordinating with the instructors to integrate their software requirements.
About EMBO Courses and Workshops
EMBO Courses and Workshops are selected for their excellent scientific quality and timelines, provision of good networking activities for all participants and speaker gender diversity (at least 40% of speakers must be from the underrepresented gender).
Organisers are encouraged to implement measures to make the meeting environmentally more sustainable.

