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EMBO Workshop

Pseudoenzyme functions across life - challenges and opportunities

10 – 13 June 2024 | Girona, Spain

  • Registration Deadline
  • 31 April 2024
  • Abstract Submission Deadline
  • 16 April 2024
  • Chosen Participants Will Be Notified By
  • 16 May 2024
  • Payment Deadline
  • 1 June 2024

Apply now!

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About the Workshop

A significant number (~10%) of enzymes are pseudoenzymes, defined by deviations in catalytically-important residues. Despite the lack of catalytic activity, pseudoenzymes impact almost all cell biological processes across life. The best-studied pseudoenzymes are pseudokinases, although examples from other enzyme families, such as pseudophosphatases, pseudoproteases, pseudo-E2 ubiquitin ligases, pseudo-deubiquitinases and pseudo-GTPases, are emerging at a fast rate.

Several principles by which pseudoenzymes function are emerging, including as scaffolds, substrate competitors or allosteric modulators of their catalytic counterparts. Understanding these functions is likely to also enhance our knowledge of signalling principles by active enzymes, that often also display moonlighting functions. Despite being a nascent field, Pseudoenzymes are emerging as unexpected therapeutic targets.

The overarching aim of this EMBO Workshop is to bring together scientists working on diverse pseudoenzymes across phyla, therefore we have themed sessions around biological processes to capture the breadth of pseudoenzymes that are under investigation and the species in which pseudoenzymes play crucial roles. The workshop will start with a session on “challenges” – how do we computationally identify enzymes and pseudoenzymes to generate a discussion on whether we have even identified them all. Given the advent of new genomic data mining tools, including machine learning algorithms and tools like AlphaFold2, we suspect that a large number of pseudoenzymes are yet to be discovered and their roles are still unidentified. We will end the workshop on “opportunities”, with a focus on the therapeutic potential of pseudoenzymes.

Image credits: Elton Zeqiraj and Phospho Biomedical Animation (https://www.phospho.co.uk/)


About EMBO Courses and Workshops

EMBO Courses and Workshops are selected for their excellent scientific quality and timelines, provision of good networking activities for all participants and speaker gender diversity (at least 40% of speakers must be from the underrepresented gender).

Organisers are encouraged to implement measures to make the meeting environmentally more sustainable.

 

Speakers

 

Programme

 

Registration

  • Registration Deadline
  • 31 April 2024
  • Abstract Submission Deadline
  • 16 April 2024
  • Chosen Participants Will Be Notified By
  • 16 May 2024
  • Payment Deadline
  • 1 June 2024

 

  • STUDENT/POSTDOCS EUR 580
  • ACADEMIC EUR 750
  • INDUSTRY EUR 800

Registration includes:

  • Accommodation for four nights of 9th, 10th, 11th and 12th June
  • Breakfast
  • Lunch
  • Dinner
  • Gala dinner
  • Poster session refreshments
  • Coffee breaks

Payment

Accepted participants will be emailed an invoice and details on how to pay.

Selection criteria

Acceptance of applicants for attending the meeting as well as the decision of whether an abstract is accepted for a poster or short talk will be based on:

Scientific quality

Subject related to workshop topics

Priority to early stage group leaders, postdoctoral fellows, and advanced PhD students

Representative distribution of gender and geographical location

Priority to participants who can cover topics that are not dealt with by invited speakers

Minimal number of representatives from the same laboratory

Abstract guidelines

Abstracts must be a maximum of 250 words, excluding title, authors and affiliations.

Poster specifications

Posters must be A0 format (841mm width x 1189mm height).

Travel grants and registration fee waivers

Travel grants and registration fee waivers are available for participants.

Selection of awardees is handled directly by the organizers. EMBO travel grants and registration fee waivers are allocated on the basis of the quality of the submitted abstract.

Applicants do not need to apply separately for these but should indicate on the registration form if they wish to be considered.

Additional travel grants are available for EMBC Associate Member States Chile, India, Singapore and Taiwan.

Special travel grants and registration fee waivers

A limited number of travel grants and registration fee waivers are available for scientists working in Croatia, Czech Republic, Estonia, Greece, Hungary, Italy, Lithuania, Luxembourg, Poland, Slovenia and Turkey. Grants are allocated on the basis of the quality of the submitted abstract.

A maximum of 700 Euros per participant are available to cover registration fees, travel, and accommodation (no additional subsistence costs can be covered). To apply, please indicate the itemized amount requested in the travel grants section of the registration form.

Child care grants

EMBO Courses and Workshops offers grants to offset additional childcare costs incurred by participants or speakers when participating at any EMBO Courses and Workshop funded meeting. Eligible costs include fees for a caregiver or child-care facility, travel costs for a caregiver, or travel costs for taking the child to the meeting etc. Please indicate on the registration form whether you would like to be considered for the grant. Please also describe how you intend to use the childcare grant and specify the sum that you will need.

Sustainability

  • Some invited speakers will be encouraged to travel by train
  • All speakers have been asked to minimise and/or offset the carbon footprint associated with their travel – local transport will be coordinated to reduce the number of trips
  • Catering will include vegetarian days, locally sourced ingredients, efforts to reduce food waste and bottled water or single-use wares will be avoided.
  • Reusable water bottles will be provided
  • Abstract books and programs will be shared in electronic form only.
  • Recycled lanyards will be used

Code of conduct

Anti-harassment and non-discrimination policy

At EMBO, we believe that harassment and discriminatory behaviour are unacceptable in any setting. EMBO's code of conduct is applicable for all participants of this EMBO meeting and can be found here.

 

Contact

Hayley Sharpe

Email: pseudoenzymes2024@gmail.com

 

 

Venue

Eden Roc Hotel

Punta de Port Salvi, s/n, 17220 Sant Feliu de Guíxols, Girona, Spain

Tel.: 00 34 972 32 01 00

Accommodation

Accommodation for four nights is included in the registration fee.

PhD students and post-docs are expected to share a double room. A limited number of single rooms are available for PIs and industry participants, or upon payment of a supplement (subject to availability).

Any additional nights should be booked and paid individually at the hotel.

Transport

By bus

Sant Feliu de Guíxols is connected to Girona, Barcelona, and the rest of the important towns of the Costa Brava by regular interurban bus lines.

Bus shuttle

Bus transfers upon arrival and departure to and from Girona or Barcelona airports will be arranged. Please indicate your interest in such a shuttle service during registration.

By car

The hotel Eden Roc is 120 km from Barcelona, via the AP-7 and the C-35 or 135 km from Perpignan, via AP-7. Once in Sant Feliu de Guíxols, Hotel Eden Roc is located at the southern end of the town.

By Plane

The Girona-Costa Brava Airport (GRO), at 31 km away, is a small airport that connects Girona with all of Europe.

The Barcelona Airport (BCN), at 119 km, is the closest international airport with daily flights to the whole world.

By train

The nearest train station is in Girona (30 km from the hotel).

About the Area

Hotel Eden Roc has an unbeatable location on the Costa Brava: on the rocks on a peninsula south of Sant Feliu de Guíxols, surrounded by the Mediterranean Sea, peace and tranquility.

This location facing the sea makes the climate very pleasant throughout the year, with temperatures that do not fall below 10ºC in winter, and do not exceed 30ºC in summer.

The hotel is located less than 1 km from the town of Sant Feliu de Guíxols, a charming town traditionally dedicated to fishing and nowadays more focused on trade and tourism. Sant Feliu preserves a beautiful old town with narrow streets and historic buildings.

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