About the Workshop
This EMBO Workshop on Nuclear Mechano-Genomics will focus on developing an in-depth understanding of the coupling between mechanical micro-environment of cells and the 3D genome organization to regulate cell behavior. While our understanding of the epigenetic biochemical factors, kinases, transcription factors and chromatin remodeling enzymes has rapidly progressed, the mechano-chemical basis of such regulatory programs is only beginning to be understood. For example, the activation of transcription factors by cell mechanics, active cytoplasmic to nuclear localization of regulatory molecules, the coupling between cytoskeletal filaments with nuclear mechanical architecture, the spatio-temporal dynamics of chromatin modulated by active physical forces, mechanics of genome regulation and its maintenance, and how alterations in this mechanical architecture of the nucleus correlates with disease pathologies are all areas of intense research in recent years. This EMBO Workshop will enhance the discussions in this area by taking advantage of highly interdisciplinary approaches and building new connections to the single-cell genomics community as well as extending more into disease implications. It will bring together physicists, engineers, computer scientists and biologists to understand the coupling between nuclear mechanics and genome regulation and its impact on diseases.
This EMBO Workshop is also an outcome of the ongoing successful “Mechano-Genomics Seminar Series” that was started during the pandemic.
About EMBO Courses and Workshops
EMBO Courses and Workshops are selected for their excellent scientific quality and timelines, provision of good networking activities for all participants and speaker gender diversity (at least 40% of speakers must be from the underrepresented gender).
Organisers are encouraged to implement measures to make the meeting environmentally more sustainable.