About the Workshop
The Hedgehog morphogen pathway is a key signalling pathway in development and stem cell regulation. Hedgehog deregulation leads to developmental and neurological diseases and is a crucial driver of several cancers. The goal of this conference is to bring together experts working on the mechanism of action of Hedgehog signalling in Developmental Biology, Disease, and Signal Transduction. The meeting will focus on the recent structural, biochemical, and cell-biological studies that shed new light on the mechanisms by which the Hedgehog signal is received on target cells and the unexpected role of cholesterol as a second messenger. Moreover, the recent advances in understanding the molecular mechanisms underlying the Hedgehog morphogen biosynthesis, its release from cells into extracellular space, and the mechanisms involved in ligand reception will be discussed. We will also cover the most recent insights into Hedgehog-dependent control of cell proliferation and differentiation in processes that range from insect morphogenesis to vertebrate limb formation, neural tube development, and bone differentiation.
Topics:
- Structural Studies on Hedgehog signalling
- Hedgehog signalling in Disease
- Mechanisms of Hedgehog signalling
- Hedgehog signalling in Development
About EMBO Courses and Workshops
EMBO Courses and Workshops are selected for their excellent scientific quality and timelines, provision of good networking activities for all participants and speaker gender diversity (at least 40% of speakers must be from the underrepresented gender).
Organisers are encouraged to implement measures to make the meeting environmentally more sustainable.
