About the Workshop
Edmond Fischer
(1920-2021)
Patricia Cohen
(1944–2020)
This workshop is dedicated to the memory of the Nobel Laureate Edmond Fischer who together with Edwin Krebs discovered reversible phosphorylation as a regulatory mechanism and Patricia Cohen for her pioneering work on protein phosphatases. Both Edmond and Patricia were passionate supporters of the phosphatase community and scholarly events such as this.
Reversible phosphorylation is a primary mode of signal transduction vital to all aspects of cellular function. Tightly controlled by the opposing activities of phosphatases and kinases, this post-translational modification mediates protein-protein interactions and regulates the catalytic activity of enzymes. Disruption of this delicate balance can have profound pathological consequences. Stigmatized as nonselective housekeeping enzymes with limited druggability, protein phosphatases have emerged as equally important to kinases in health and disease. The aim of this EMBO Workshop is to bring together leading scientists and trainees in reversible phosphorylation, signal integration, and drug discovery to present and discuss their latest findings, challenges, and gaps in our knowledge. Topics will include protein phosphatases in immunobiology and immunotherapy, cancer biology, and structure-function. A special session will be dedicated to innovative ways of targeting this family of enzymes and potential therapeutic benefits, and tributes will be given to pioneers of the field.
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About EMBO Courses and Workshops
EMBO Courses and Workshops are selected for their excellent scientific quality and timelines, provision of good networking activities for all participants and speaker gender diversity (at least 40% of speakers must be from the underrepresented gender).
Organisers are encouraged to implement measures to make the meeting environmentally more sustainable.