About the Workshop
After two decades of research, intrinsically disordered regions (IDRs), protein regions that lack stable secondary or tertiary structure, are established as a widespread phenomenon. One-third of the human proteome is intrinsically disordered, however, these regions still remain one of biology’s most intriguing blind spots. Recent experimental advances have resulted in a huge growth in our understanding of the functional role of these regions and their relevance in disease. These studies have revealed that IDRs direct proteins from their synthesis to destruction, by regulating and coordinating their interactome, processing, localisation and degradation.
This EMBO Workshop will highlight recent breakthroughs in IDR research by presenting state-of-the-art research tackling three open questions: What are their functional roles? How do their modification state and dynamic conformations modulate protein function? How are their functions altered in disease and can they be therapeutically targeted?
The EMBO Workshop will assemble researchers that use diverse experimental and computational approaches to study IDRs. Notably, cell biologists characterising the functional modules and their regulation, systems biologists discovering novel interactions on a proteome-wide scale, and bioinformaticians developing in-silico analysis tools and resources. We will highlight complementary aspects of these approaches to promote the cross-disciplinary collaboration crucial for a comprehensive understanding of IDRs.