About the Workshop
During the last few years, a breakthrough has taken place in our understanding of chromatin structure at interphase. Not only a system of chromatin loops and boundaries was found to be generally present at interphase in metazoans, but a strong evolutionary conservation of the system was observed. Moreover: 1) correlations were found between features of the 3D structure of interphase chromatin and the compositional (isochore) landscapes of the genome; and 2) topological chromatin changes were shown to cause deleterious changes in gene expression.
The main theme of the EMBO Workshop on “Evolution in the Time of Genome Architecture” will concern the impact of these observations on investigations in genome evolution. The general idea of the Workshop is to have the interaction of both researchers interested in chromatin architecture and its influence on gene regulation and researchers involved in genome evolution. We have consulted on this subject the people listed below as confirmed speakers (a mix of established investigators, with the right proportion of female speakers, plus 10-15 younger researchers selected from the participants). Not only the invited speakers sent us an enthusiastic support for the new EMBO activity in evolution, but also expressed a strong interest in participating in this Workshop.