About the Workshop
Autophagy is a ubiquitous and evolutionarily conserved process in eukaryotes that degrades cytosolic components in the lysosome. It plays an important role in maintaining cellular homeostasis, especially under physiological and patho-physiological stress conditions. The past decade has seen an exponential expansion of our knowledge about the regulation and molecular mechanisms of this pathway. Autophagy is tied to stress responses through a number of key signaling pathways, and is orchestrated by a series of core autophagy proteins (ATG proteins) that are evolutionarily conserved. While studies on ATG proteins in mammals and in a multitude of model systems continue to unveil the molecular basis and new facets of the mechanisms underlying autophagy, a series of recent discoveries has revealed the great therapeutic potential of autophagy modulation in a variety of human diseases. The aim of this EMBO Workhop is to integrate diverse perspectives on the function of autophagy from the fields of genetics, cell biology, oncology, infection and immunity, metabolism, neurodegeneration and drug discovery. We will provide the optimal venue for the promotion of exchanges between young and established scientists, clinicians and industry, to foster the growth of translational autophagy research.