About the Workshop
This EMBO Workshop will focus on the molecular mechanisms of telomere biology and how this is compromised in human genetic disorders, ageing and cancer. This reflects exciting recent developments in the field linking shelterin and telomerase pathway mutations to a range of human diseases. Together with these clinical developments, recent technical advances have also revealed unexpected new insights into telomere biology at the level of single molecules and in whole organisms. Thus, new research insights in this field are arising constantly, which we aim to promote by bringing together basic, translational and clinical telomere researchers who are studying the mechanisms underlying telomere homeostasis and exploiting these recent discoveries for the benefit of human health.
The principle themes of the meeting will therefore focus on the latest advances in telomere function and regulation and how this can be exploited for diagnostics, anti-cancer approaches and treatment/management of telomere dysfunction disorders. A major objective of the meeting will be to provide a forum for open and stimulating discussions between key basic, translational and clinical scientists and young researchers who have recently joined the field.
Topics to be covered include:
- Telomere replication and length regulation
- Stem cells and cancer
- Telomerase biogenesis and function
- Consequences of telomere dysfunction
- Telomere proteins and protein modifications
- Telomere length and disease
- Mechanisms of telomere maintenance
- Telomeric RNA and chromatin