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Pseudoenzymes 2018: From molecular mechanisms to cell biology

16 – 19 May 2018 | Sardinia, Italy

  • REGISTRATION DEADLINE
  • 30 April 2018
  • ABSTRACT SUBMISSION DEADLINE
  • 16 April 2018
  • CHOSEN PARTICIPANTS WILL BE NOTIFIED BY
  • 01 May 2018
  • PAYMENT DEADLINE
  • 07 May 2018

Apply now!

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About the Workshop

PseudoenzymesThe last decade has seen a surge in studies showing how pseudoenzymes (enzymes predicted to lack catalytic activity) employ innovative and unexpected mechanisms to regulate biological functions. Pseudoenzymes act in diverse ways, including by allosterically activating conventional enzymes, acting as scaffolds for signalling complex assembly, and as molecular switches.

The best-studied pseudoenzymes are pseudokinases, although examples from other enzyme families, such as pseudophosphatases, pseudoproteases, pseudo-E2 ubiquitin ligases, pseudo-deubiquitinases (pseudo-DUBs) and pseudo-GTPases, are emerging at a fast rate. It is now clear that almost every enzyme family contains some inactive “rogue” members. While the precise number may vary depending on the enzyme class, it is reasonable to expect that 5-10% of genes in each enzyme family will turn out to be inactive pseudoenzymes.

Many pseudoenzymes are essential regulators of biological processes and because of their widespread occurrence, pseudoenzymes have garnered the interest of bioinformaticians, structural biochemists, cell biologists, chemists and clinicians. Detailed studies of pseudoenzymes have advanced our knowledge of how they perform non-catalytic functions, and unexpectedly, they have also provided insights on the functional aspects of their active counterparts.

An interesting twist on the emergence of important signalling roles for pseudoenzymes is that that their functions can be modulated by small-molecule compounds. As such, pseudoenzymes provide additional disease targets for therapeutic intervention.

To celebrate, nurture and advance this exciting field, the world’s second pseudoenzyme meeting will take place in Sardinia, Italy in May 2018. This EMBO meeting brings together current experts in the field to help shape thinking and capitalise on our knowledge of genomes and proteomes to advance the pseudoenzyme field into the 21st century. This EMBO Workshop follows a highly successful Pseudoenzyme meeting in Liverpool in September 2016 (website).

Major themes that will be explored at this meeting include:

· Evolution of pseudoenzymes

· Biochemistry and cell biology of pseudoenzymes

· Pseudoenzymes in disease

· Pseudoenzymes as therapeutic targets

· Emerging areas in pseudoenzyme biology

The EMBO Workshop will be attractive to candidates interested in enzyme function and evolution, cellular signalling and molecular mechanisms of disease.

RNAsePseudo dubHER3 Dimer
 

Speakers

 

Programme

 

Registration

  • REGISTRATION DEADLINE
  • 30 April 2018
  • ABSTRACT SUBMISSION DEADLINE
  • 16 April 2018
  • CHOSEN PARTICIPANTS WILL BE NOTIFIED BY
  • 01 May 2018
  • PAYMENT DEADLINE
  • 07 May 2018

 

  • STUDENT/POSTDOCS GBP 450
  • ACADEMIC GBP 500
  • INDUSTRY GBP 800

Registration includes:

  • Accommodation for core nights (16, 17 and 18th of May)
  • Access to all sessions
  • Breakfast
  • Lunch
  • Dinner
  • Gala Dinner
  • Welcome reception
  • Coffee breaks
  • Childcare (see below or enquire for details)

Payment

Accepted applicants will receive payment details by email.

Selection criteria

Acceptance of applicants for attending the meeting as well as the decision of whether an abstract is accepted for a poster or short talk will be based on scientific merit only.

Preference will be given to applicants submitting abstracts with non-published work.

Abstract guidelines

Abstracts must be a maximum of 250 words, excluding title, authors and affiliations.

Poster specifications

Posters must be A0 format (841mm width x 1189mm height).

Additional Information

ACCOMMODATION

The majority of participants will be housed in twin rooms. Stay in single rooms may be requested, but these will be provided at extra cost.

CHILDCARE DURING THE CONFERENCE

Childcare should be arranged in advance and is offered for children between the age of 3 months and 3 years to registered participants. Due to budget limitations, registration will be on a first-come, first-served basis. Please enquire for more details.

TRAVEL GRANTS

A limited number of travel grants are available for eligible participants. Applicants do not need to apply separately for travel grants for this event but should indicate on the registration form if they wish to be considered for a travel grant. Selection of awardees is based on scientific merit and handled directly by the organizer who will notify all eligible participants.

All participants working in EMBC member countries and associate member states are eligible. However, priority will be given to participants of any nationality working in laboratories in: Croatia, Czech Republic, Estonia, Greece, Hungary, Italy, Malta, Lithuania, Poland, Portugal, Slovakia, Slovenia, Spain and Turkey as well as from lower income economies.

Travel grants for participants from EMBC Associate Member States and co-operation partner countries, currently India, Singapore and Taiwan are also encouraged.

 

Contact

Elton Zeqiraj

Email: pseudoenzymes2018@gmail.com

 

 
venue map

Venue

Hotel Flamingo Resort

SS 195, Km 33,800,
Santa Margherita di Pula, Sardegna
IT- 09010

ITALY

Website

Accommodation

The majority of participants will be housed in twin rooms. Please indicate whom you would like to share a room with. Stay in single rooms may be requested, but these will be provided at extra cost.

Transport

TRAVEL

Directions to arrive by car at the Hotel Flamingo from Cagliari:

Take the airport exit (via the Trasvolatori) proceeding towards Cagliari taking the ramp onto SS130. Once entered onto the 4-lane road, continue for about 4.6 km. Keep left at the fork, follow the signs for the SS195/Pula and enter the SS195. Drive approximately 35.9 km keeping the SS195 road, crossing about 8 roundabouts. Pass the town of Pula without entering the village and turn left at km 33.800 and the hotel entrance after about 1 km.

Directions to arrive by car at the Hotel Flamingo from the port of Cagliari:

Once arrived by car from the ferry, drive out to the “Via riva di Ponente” and keep left at the next light and turn away from the Playa, following the signs to the SS195/Pula and enter the SS195. Drive approximately 35.9 km keeping the SS195 road, crossing about 8 roundabouts. Pass the town of Pula without entering the village and turn left at km 33.800 and the hotel entrance after about 1 km.

Directions to get there by bus from the airport to the Hotel Flamingo Cagliari:

From the airport take the ARST bus to Cagliari. The bus stops right inside the station ARST. From the station take the ARST bus to Sant’Anna Arresi. The bus takes 50 minutes to take you to Santa Margherita di Pula, which is approximately 1 km from the Hotel Flamingo Resort.

Main distances

Distances from the airports of Sardinia
Cagliari Elmas: Km. 43, along the S.S. 195
Olbia: Km. 298, along the S.S. 131 Bis
Alghero: Km. 245, along the S.S. 131

Sponsors

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