About the Workshop
Neuronal circuits in the cerebral cortex consist of excitatory pyramidal cells and inhibitory interneurons. Although neglected for a long time, interneurons are now recognized as essential elements in cortical function. Through mostly inhibitory mechanisms, interneurons regulate the activity of glutamatergic pyramidal cells and prevent hyperexcitability. Interneurons also have important network properties, through which they synchronize and control the rhythmic output of pyramidal cells. Consistently, increasing evidence suggest that disruption of interneuron function underlies neuropsychiatric conditions such as schizophrenia and autism spectrum disorders.
In this EMBO Workshop, we will bring together world-class scholars with very different perspectives on the biology of cortical interneurons. The main goal of our meeting is to encourage the interaction between experts with very diverse backgrounds, from developmental neurobiology to systems neuroscience, to address some of the more compelling questions in this flourishing field of research. We will reproduce the format of a meeting that we have successfully organized before but focusing on a completely new set of questions. Experts will discuss new advances on interneuron disorders, emerging aspects on the biology of human interneurons, the impact of interneuron function on cortical operations, and novel insights into the origins of their diversity.