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EMBO Workshop

From epigenome towards epitranscriptome in cell fate choice

14 – 17 October 2018 | Capri, Italy

  • Abstract Submission
  • 01 April 2018 – 15 June 2018
  • Chosen Participants Will Be Notified By
  • 30 June 2018
  • Travel Grant Application
  • 01 April – 15 June 2018
  • Registration Deadline
  • 31 July 2018

Apply now!

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About the Workshop

In the central dogma of molecular biology, RNA was thought only to pass genetic information from DNA to protein. Most recent findings strongly indicate that RNA modifications, like mRNA methylation, play dynamic regulatory roles that are analogous to the reversible epigenetic modifications of DNA and histone proteins. Understanding the function and mechanisms of the dynamic RNA modifications, which are termed 'RNA epigenetics', represents a new challenge at the frontier between different disciplines, such as biochemistry, epigenetics and cutting-edge technology.

Reversible RNA modifications add a new dimension to the developing picture of post-transcriptional regulation of gene expression. This new dimension awaits integration with transcriptional regulation, i.e. DNA modifications, to decipher the multi-layered information that controls a plethora of biological functions. Thus, in the era of advanced technologies, the exciting next step is to move from mapping nucleotide modifications to understanding how they contribute to biological processes.

This EMBO Workshop involves sessions dedicated to recent advances in the epigenomic and epitranscriptomic regulation of stem cell pluripotency and differentiation, organismal development, and how their alteration brings about human diseases. Particular emphasis on approaches enabling targeted manipulation of epigenetic marks, which are revolutionising the field, will be addressed.

Topics to be covered include:

1. Dynamic DNA and RNA modifications: Writers, erasers, and readers. This session will be dedicated to the discovery and functional elucidation of the enzymes dynamically modifying and demodifying DNA and RNA molecules. Also, progress made on identification and characterization of proteins mediating the effects of these modifications into biological function will be discussed.

2. Decoding the function of DNA and RNA modifications: Insights from epigenome editing and other approaches. The second session will provide new insights on the emerging approaches useful for an enhanced and more accurate interpretation of DNA and RNA dynamics. For instance, the targeted deposition or removal of chromatin modifications promises to be a powerful tool in basic research, to study gene function and chromatin biology, and also in molecular medicine.

3. DNA and RNA Epigenetics in Stem Cell and Development. This session will discuss the latest advances on the epi-control of the mechanisms underlying the cell fate decision and early developmental processes, with a special focus on the embryonic and adult stem cells. Moreover, DNA and RNA methylation will be discussed in the context of reprogramming events in the developing mouse germ line and zygote.

4. Epigenomes and Epitranscriptomes: A gateway to understanding diseases. In this session, the discussion will be focused on how understanding the regulation of DNA and RNA modifications paves the way towards identifying causes and cures for human diseases, with particular emphasis on cancer, muscle diseases and autoimmune disorders.

 

Speakers

 

Programme

 

Registration

  • Abstract Submission
  • 01 April 2018 – 15 June 2018
  • Chosen Participants Will Be Notified By
  • 30 June 2018
  • Travel Grant Application
  • 01 April – 15 June 2018
  • Registration Deadline
  • 31 July 2018

 

  • STUDENT EUR 520
  • ACADEMIC/POSTDOCS EUR 620
  • INDUSTRY EUR 920

Registration includes:

  • Meals (breakfast, lunch, dinner, and coffee break)
  • Full Accommodation
  • Participation in all lectures
  • Workshop material

Payment

Successful participants will receive an email with the payment link.

Selection criteria

The workshop is limited to 120 participants. Selection criteria will be based on:

  • CV
  • Abstract
  • Motivation letter

Abstract guidelines

All applicants are requested to fill out the online application form by submitting an abstract (download the abstract form on the online application page) on their current research and present a poster.

Short oral presentations will be selected from amongst the submitted abstracts. The selected participants for presentations will be notified by 15 September, 2018; posters are therefore not required.

Poster specifications

Poster size must be maximum 90cm width x 110cm height

Due to limited space, posters exceeding the indicated size cannot be displayed.


Travel grants

A limited number of travel grants are available for participants. Applicants do not need to apply separately for travel grants for this event but should indicate on the registration form if they wish to be considered for a travel grant. Selection of awardees is handled directly by the organizer who will notify all eligible participants. More information is available at EMBO Travel Grants' page.

ICGEB grants will also be available for selected participants who are ICGEB Member State nationals, with preference being given to students and junior scientists in the early stage of their career currently residing outside of Italy. Grants will include accommodation, meals and fee waive.

EPIGEN grants will be reserved to young scientists (PhD students and Post-docs) from EPIGEN (Epigenomics Flagship Project) italian laboratories covering the registration fee. Applicants for EPIGEN grants have to fill the relative section in the Online Application page.

InterOmics grants will be reserved for young scientists (PhD students and Post-docs) from InterOmics Flagship Project Italian laboratoris covering the registration fee and the travel costs. Applicants for InterOmics grants will be asked to fill the relative section in the Online Application page.

 

Contact

Anna Maria Aliperti

Email: workshop@igb.cnr.it

Phone: +39 81 6132401

Federica Staempfli

Email: federica.staempfli@igb.cnr.it

Phone: +39 81 6132402

Co-ordinator

Maria Giuseppina Miano
Maria Giuseppina MianoInstitute of Genetics and Biophysics "ABT" - CNR, IT

 

 

Venue

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Hotel La Palma, Capri Naples

Via V. Emanuele 39, 80073 CAPRI (Na) Italy

Ph. +39 081 8370133

Fax +39 081 8376966

Accommodation

Accommodation and meals are provided by the Hotel La Palma, a traditional Capri Hotel located within 2 minutes walking distance from the famous "Piazzetta".

The location has always been highly regarded by past participants because of the intimate, fun, informal environment. Most importantly, it is highly conducive to fostering interactions. In particular, the hotel has wonderful common spaces, including a terrace and a hall that has many sofas and armchairs where many informal scientific discussions have been held.

Participants will be lodged in double rooms; a very limited number of single rooms are available.

Transport

If you arrive at the Naples Capodichino Airport, you can either take a taxi (taxis should display in the car exact fares, avoid taxis that don’t display fares and counter) or take the Airport bus: Alibus ANM—the ticket may be purchased on board (4 Euros) and is valid for 90 minutes for use on all local public transportation — to Piazza Municipio. Buses depart approximately every 30 minutes from 6:00 am to 11:40 pm.

If you arrive at Rome Leonardo da Vinci Airport, take the Fiumicino Express Bus to Naples (Napoli MetroPark) or alternatively take the Airport train to Stazione Termini and then a train to Naples Stazione Centrale. For timetables, please check the link below. From the station, you can either take a taxi or a bus to Piazza Municipio (it takes about 30 minutes).

Hydrofoils and ferry-boats to Capri depart from Molo Beverello, which is in front of Piazza Municipio. Because boats run from 7am to about 6pm (crossing takes about 50 min), you should arrive in Naples no later than 5pm.
 All boats reach the Capri Marina Grande port. From there, take the Cable Railway to Piazza Umberto (the famous Piazzetta) and then take a two minutes walk to the Hotel La Palma (Via Vittorio Emanuele 39, Capri, Tel. +39/081-8370133; Fax +39/081-8376966). The Island can also be reached from Sorrento and Positano.

Useful Links:

Train Info

Naples Airport "Capodichino"

Rome Airport "Leonardo Da Vinci"

Fiumicino Express Bus

Alibus ANM timetable

Hydrofoils and ferry-boats Naples-Capri

About the Area

Hotel La Palma is in the centre of Capri, close to the famous square Umberto I, the “Piazzetta”. It is in the perfect position to reach the incredible sites of the Island: i Giardini di Augusto, Via Krupp, La Certosa and the Faraglioni.

The Piazzetta can be reached from the port by taxi, bus, and funicular railway. For more information of how to get around, see here.

Supporters

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