About the Workshop
The molecular process of Antigen Processing and Presentation leads to T lymphocyte activation and function to enable CD4 T cells to potentiate the humoral and cellular immune responses, and CD8 T cells to eliminate infected or tumoral cells. This process is thus the basis for vaccination against infectious diseases and is critically involved in prevailing human diseases, such as autoimmunity. Furthermore, the success of cancer immunotherapy, which in the past couple of years is dramatically changing the clinical expectations of cancer patients, is deeply rooted in how antigens are presented by cancer cells to T lymphocytes.
This EMBO Workshop will cover all aspects of the topic including the cell biology of assembly of MHC class I, class II and class I-like molecules; intracellular trafficking and quality control; the immunopeptidome; the structural biology of MHC and TCR; in vivo direct and cross-presentation by professional dendritic cells; and finally, the impact of research in these areas on prevention and treatment of infectious diseases, autoimmune diseases and cancer.
Header image credit: Miguel Marcilla and César Santiago, CNB, Madrid, Spain